WYKAZ PUBLIKACJI NAUKOWYCH, OD ROKU 2000, NAUKOWCÓW BIORĄCYCH UDZIAŁ W PRACACH CD.

Wykaz zawiera jedynie publikacje w czasopismach z tzw. Listy Filadelfijskiej.

 


  Rok 2007

  1. Andruszkiewicz R., Koszel D. A simple access to o-acyl bicyne. Polish J. Chem.., 81, 295-298 (2007)


  2. Ashok B.T., Tadi K., Garikapaty V., Chen Y., Huang Q., Banerjee D., Konopa J., Tiwari R.K. Preclinical toxicological examination of a putative prostate cancer-specific 4-methyl-1-nitroacridine derivative in rodents. Anti-Cancer Drugs., 18, 87-94 (2007)


  3. Bartoszek A.. Mutagenic, Carcinogenic, and Chemopreventive Compounds in Foods. In: Chemical and functional properties of food components. Third edition., Z.E. Sikorski (ed.)., Boca Raton : CRC Press Taylor & Francis Group, 2007., pp. 451-485


  4. Bram E., Ifergan I., Grimberg M., Lemke K., Składanowski A., Assaraf Y. C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells. Biochem. Pharmacol.., 74, 41-53 (2007)


  5. Cieśliński H., Białkowska A., Długołęcka A., Daroch M., Tkaczuk K., Kalinowska H., Kur J., Turkiewicz M. A cold-adapted esterase from psychrotrophic Pseudoalteromonas sp. strain 643A. Arch. Microbiol., 187, 27- 36 (2007)


  6. Czajgucki Z., Zimecki M., Andruszkiewicz R. The immunoregulatory effects of edeine analogues in mice. Cell. Molec. Biol. Lett., 12, 149-161 (2007)


  7. Czub J., Borowski E., Bagiński M. Interactions of amphotericin B derivatives with lipid membranes - a molecular dynamics study. Biochim. Biophys. Acta 1768, 2616-2626 (2007)


  8. Doskaya M., Kalantari-Dehaghi M., Walsh C.M., Hiszczyńska-Sawicka E., Davies H.D., Felgner P.L., Larsen L.S., Lathrop R.H., Hatfield W.G., Schulz J.R., Guruz Y., Jurnak F. GRA1 protein vaccine confers better immune response compared to codon-optimized GRA1 DNA vaccine. Vaccine, 25, 1824- 1837 (2007)


  9. Dzieduszycka M., Stefańska B., Gawrońska M., Arciemiuk M., Borowski E. Synthesis of new polycyclic anthracenodione analogs with hetero- or carbocyclic ring(s) fused to the chromophore system. Polish J. Chem. 81 535- 545 (2007)


  10. Filipkowski P., Duraj-Thatte A., Kur J. Identification, cloning, expression, and characterization of a highly thermostable single-stranded- DNA-binding protein (SSB) from Deinococcus murrayi. Protein Express. Purif., 53, 201-208 (2007)


  11. Filipkowski P., Kur J. Identification and properties of the Deinococcus grandis and Deinococcus proteolyticus single-stranded DNA binding proteins (SSB). Acta Biochim. Polon., 54, 79-87 (2007)


  12. Holec L., Hiszczyńska-Sawicka E., Gąsior A., Brillowska-Dąbrowska A., Kur J. Use of MAG1 recombinant antigen for diagnosis of Toxoplasma gondii infection in humans. Clin. Diagn. Labor. Immunol., 14, 220-225 (2007)


  13. Koba M., Konopa J. Interactions of antitumor triazoloacridinones with DNA. Acta Biochim. Polon., 54, 297-306 (2007)


  14. Konieczny M., Konieczny W., Pirska D., Bułakowska A., Sabisz M., Składanowski A., Wakieć R., Augustynowicz-Kopeć E., Zwolska Z. Synthesis of oxathiolone fused chalkones bearing O-aminoalkyl side chain. Comparison of stability of isomeric benzoxathiolones under alkylation reaction conditions. Heterocycles 71, 2595-2615 (2007)


  15. Konieczny M., Konieczny W., Sabisz M., Składanowski A., Wakieć R., Augustynowicz-Kopeć E., Zwolska Z. Acid-catalysed synthesis of oxathiolone fused chalkones. Comparison of their activity toward various microrganisms and human cancer lines. Eur. J. Med. Chem., 42, 729-733 (2007)


  16. Konieczny M., Konieczny W., Sabisz M., Składanowski A., Wakieć R., Augustynowicz-Kopeć E., Zwolska Z. Synthesis of isomeric, oxathiolone fuded chalcones and comparison of their activity toward various microorganisms and human cancer cell lines. Chem. Pharm. Bull., 55, 817-820 (2007)


  17. Krawczyk B., Leibner J., Barańska-Rybak W., Samet A., Kur J. ADSRRS- fingerprinting and PCR MP techniques for studies of intraspecies genetic relatedness in Staphylococcus aureus. J. Microbiol Methods., 71, 114-122 (2007)


  18. Krawczyk B., Leibner J., Stojowska K., Kur J. PCR Melting Profile method for genotyping analysis of vancomycin-resistant Enterococcus faecium isolates from hematological unit patients. Polish J. Microbiolol., 56, 65- 70 (2007)


  19. Kur M., Piątek R., Kur J. A two-plasmid Escherichia coli system for expression of Dr adhesions. Protein Express. Purif.., 55, 361-367 (2007)


  20. Larsen A.K., Składanowski A. Perturbation of cellular functions by topoisomerase II inhibitors: all roads lead to cell death? In: Apoptosis, Senescence and Cancer. Second Edition., D.A. Gewirtz, S.E. Holt, S. Grant. (eds.), Humana Press (2007) pp. 407-422


  21. Makowski K., Bialkowska A., Szczęsna-Antczak M., Kalinowska H., Kur J., Cieśliński H., Turkiewicz M. Immobilized preparation of cold-adapted and halotolerant antarctic á-galactosidase as a highly stable catalyst in lactose hydrolysis. // FEMS Microbiol. Ecol., 59, 535-542 (2007)


  22. Melcer A., Łącka I., Gabriel I., Wojciechowski M., Liberek B., Wiśniewski A., Milewski S. Rational design of N-alkyl derivatives of 2-amino-2-deoxy-D- glucitol-6-P as antifungal agents. Bioorg. Med. Chem. Lett., 17, 6602-6606 (2007)


  23. Nowicka A., Zabost E., Donten M., Mazerska Z., Stojek Z. Electroanalytical and spectroscopic procedures for examination of interactions between double stranded DNA and intercalating drug. Anal. Bioanal. Chem., 389, 1931-1940 (2007)


  24. Nowicka A., Zabost E., Donten M., Mazerska Z., Stojek Z. Spectroelectroanalytical properties of antitumor agent C1311. Electroanalysis 19 214-219 (2007)


  25. Olchowy J., Gabriel I., Milewski S.: Functional domains and interdomain communication in Candida albicans glucosamine-6-phosphate synthase. Biochem. J., 404, 121-130 (2007)


  26. Pietkiewicz H., Hiszczyńska-Sawicka E., Kur J., Petersen E., Nielsen H.V., Paul M., Stankiewicz M., Myjak P. Usefulness of Toxoplasma gondii recombinant antigens (GRA1, GRA7 and SAG1) in an immunoglobulin G avidity test for the serodiagnosis of toxoplasmosis. Parasitol. Res., 333-337 (2007)


  27. Raczyńska J., Olchowy J., Konariev P., Svergun D., Milewski S., Rypniewski W. The crystal and solution studies of glucosamine-6-phosphate synthase from Candida albicans. J. Mol. Biol., 372, 672-688 (2007)


  28. Sachadyn P., Stanisławska-Sachadyn A., Kur J. A bifunctional chimeric protein consisting of MutS and á-galactosidase. J. Biotechnol., 127, 229- 234 (2007)


  29. Składanowski A., Bożko P., Sabisz M., Larsen A.K. Dual inhibition of PI3K/Akt signaling and the DNA damage checkpoint in p53-deficient cells with strong survival signaling: implications for cancer therapy. Cell Cycle., 6, 2268 - 2275 (2007)


  30. Skwarska A., Augustin E., Konopa J. Sequential induction of mitotic catastrophe followed by apoptosis in human leukemia MOLT4 cells by imidazoacridinone C-1311. Apoptosis., 12, 2245-2257 (2007)


  31. Ślisz M., Cybulska B., Grzybowska J., Czub J., Prasad R., Borowski E. The mechanism of overcoming multidrug resistance (MDR) of fungi by amphotericin B and its derivatives. J. Antibiot., 60, 436 - 446 (2007)


  32. Wakieć R., Prasad R., Morschhauser J., Barchiesi F., Borowski E., Milewski S. Voriconazole and multidrug resistance in Candida albicans. Mycoses 50, 109-115 (2007)


  33. Wanarska M., Hildebrandt P., Kur J. A freeze-thaw method for desintegration of Escherichiacoli cells producing T7 lysozyme used in pBAD expression systems. Acta Biochim. Polon., 54, 671-672 (2007)


  34. Wiśniewska A., Chrapkowska A., Kot-Wasik A., Konopa J., Mazerska Z. Metabolic transformations of antitumor imidazoacridinone, C-1311, with microsomal fractions of rat and human liver. Acta Biochim. Polon., 54, suppl. 4, 831-838 (2007)


  35. Zalewska B., Stangret J., Bury K., Wojciechowski M., Kur J., Piątek R. DAF - and collagen-binding properties of chimeric Dr fimbriae. Microbiology 153, 2733-2742 (2007)





     


    Rok 2006

  36. Ashok B.T., Tadi K., Banerjee D., Konopa J., Iatropoulos M., Tiwari R.K., Pre-clinical toxicology and pathology of 9-(2'- hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), a novel anti-cancer agent in male Beagle dogs, Life Sciences, 79, 1334- 1342 (2006).


  37. Augustin E., Moś-Rompa A., Skwarska A., Witkowski J.M., Konopa J. Induction of G2/M phase arrest and apoptosis of human leukemia cells by potent antitumor triazoloacridinone C-1305, Biochem. Pharmacol., 72, 1668- 1679 (2006)


  38. Bagiński M., Czub J., Sternal K. Interaction of amphotericin B and its selected derivatives with membranes: molecular modeling studies., Chem. Rec. 6., 320-332 (2006)


  39. Czajgucki Z., Andruszkiewicz R., Kamysz W. Structure-activity relationship studies on the antimicrobial activity of novel edeine a and d analogues. J. Peptide Sc.. 12, 653-662 (2006)


  40. Czub J., Bagiński M. Comparative molecular dynamics study of lipid membranes containing cholesterol and ergosterol. Biophys. J., 90, 2368-2382 (2006).


  41. Czub J., Bagiński M. Modulation of amphotericin B membrane interaction by cholesterol and ergosterol - a molecular dynamics study. J.. Phys. Chem. B, 110, 16743-16753 (2006).


  42. Dzieduszycka M., Bontemps-Gracz M.M., Stefańska B., Martelli S., Piwkowska A., Arciemiuk M., Borowski E. Synthesis of 7-oxo-7H- naphtho[1,2,3-de]quinoline derivatives as potential anticancer agents active on multidrug resistant cell lines. Bioorg. Med. Chem., 14, 2880- 2886 (2006)


  43. Filipkowski P, Duraj-Thatte A, Kur J., Novel thermostable single- stranded DNA-binding protein (SSB) from Deinococcus geothermalis. Arch. Microbiol., 186, 129-137 (2006)


  44. Filipkowski P, Koziatek M, Kur J., A highly thermostable, homodimeric single-stranded DNA-binding protein from Deinococcus radiopugnans. Extremophiles, 10, 607-614 (2006)


  45. Gatkowska J, Hiszczyńska-Sawicka E, Kur J, Holec L, Długońska H., Toxoplasma gondii: An evaluation of diagnostic value of recombinant antigens in a murine model. Exptl. Parasitol., 114, 220-227 (2006)


  46. Grijalba M.T., Cheron M., Borowski E., Bolard J., Schreier S. Modulation of polyene antibiotics self-association by ions from the Hormeister series., Biochim. Biophys. Acta, 1760, 973-979 (2006)


  47. Jędrzejczak R, Dauter M, Dauter Z, Olszewski M, Długołęcka A, Kur J., Structure of the single-stranded DNA-binding protein SSB from Thermus aquaticus. Acta Crystallogr. D., 62, 1407-1412 (2006)


  48. Jędrzejczak R, Dauter Z, Dauter M, Piątek R, Zalewska B, Mróz M, Bury K, Nowicki B, Kur J., Structure of DraD invasin from uropathogenic Escherichia coli: a dimer with swapped beta-tails., Acta Crystallogr. D., 62, 157-164 (2006)


  49. Krawczyk B, Samet A, Leibner J, Śledzińska A, Kur J., Evaluation of a PCR melting profile technique for bacterial strain differentiation. J. Clin. Microbiol. 44, 2327-2332 (2006)


  50. Milewski, S., Gabriel, I., Olchowy, Enzymes of UDP-GlcNAc biosynthesis in yeast. Yeast 23, 1-14 (2006)


  51. Milewski, S., Janiak, A., Wojciechowski, M., Structural analogues of reactive intermediates as inhibitors of glucosamine-6-phosphate synthase and phosphoglucose isomerase, Arch. Biochem. Biophys. 450, 39-49 (2006).


  52. Nowicka A.M., Zabost E., Donten M., Mazerska Z., Stojek Z., Electrooxidation of dissolved dsDNA backed by in situ UV-Vis spectroscopy, Bioelectrochemistry, 71, 126-131 (2006).


  53. Olchowy, J., Kur, K., Sachadyn, P., Milewski, S., Construction, purification and functional characterisation of His-tagged Candida albicans glucosamine-6-phosphate synthase expressed in Escherichia coli, Protein Expr. Purifi. 46, 309-315 (2006)


  54. Pietkiewicz H, Hiszczyńska-Sawicka E, Kur J, Petersen E, Nielsen HV, Paul M, Stankiewicz M, Myjak P., Usefulness of Toxoplasma gondii recombinant antigens (GRA1, GRA7 and SAG1) in an immunoglobulin G avidity test for the serodiagnosis of toxoplasmosis. Parasitol. Res., 100, 333- 337 (2006)


  55. Polkowska Ż., Kozłowska K., Mazerska Z., Górecki T., Namieśnik J. Volatile organohalogen compounds in human urine: The effect of environmental exposure, Chemosphere, 62, 626-640 (2006).


  56. Seroka P., Płosiński M., Czub J., Sowiński P., Pawlak J. Monosaccharide as internal probes for the determination of the absolute configuration of 2-butanol. Magn. Reson. Chem. 44, 123-138 (2006)


  57. Stanisławska-Sachadyn A, Sachadyn P, Ihle K, Sydorczuk C, Wiejacha K, Kur J., The construction of bifunctional fusion proteins consisting of MutS and GFP. J. Biotechnol., 121, 134-143 (2006)


  58. Wanarska M, Kur J, Pladzyk R, Turkiewicz M., Thermostable Pyrococcus woesei beta-D-galactosidase - high level expression, purification and biochemical properties., Acta Biochim. Polon., 52, 781-787 (2005)





     


    Rok 2005

  59. Andruszkiewicz R., Radowski M., Czajgucki Z, Efficient synthesis of orthogonally protected spermidine and norspermidine derivatives., Synth. Commun. 2005, vol. 35, 1085-1094.


  60. Andruszkiewicz R., Zieniawa T., Walkowiak A., Anticandidal properties of N-acylpeptides containing an inhibitor of glucosamine-6-phosphate synthase. J. Enzyme Inhib. Med. Chem. 2005, vol. 20, 115-121.


  61. Bagiński M., Sternal K., Czub J., Borowski E., Molecular modelling of membrane activity of amphotericin B, a polyene macrolide antifungal antibiotic., Acta Biochim. Polon. 2005, vol. 52, 655-658.


  62. Borowski E., Bontemps-Gracz M.M., Piwkowska A., Strategies for overcoming ABC-transporters-mediated multidrug resistance (MDR) of tumor cells. Review., Acta Biochim. Polon. 2005, vol. 52, 609-627.


  63. Cieślinski H., Kur J., Białkowska A., Baran I., Makowski K., Turkiewicz M., Cloning, expression, and purification of a recombinant cold-adapted beta-galactosidase from antarctic bacterium Pseudoalteromonas sp 22b. Protein Expr. Purif. 2005, vol. 39, 27-34.


  64. Das M., Hart-Van Tassell A., Urvil P.T., Lea S., Pettigrew D., Anderson K.L., Samet A., Kur J., Matthews S., Nowicki S., Popov V., Goluszko P., Nowicki B.J., Hydrophilic domain II of Escherichia coli Dr fimbriae facilitates cell invasion. Infect. Immun. vol. 73, 6119- 6126 .


  65. Fogolari F., Moroni E., Wojciechowski M., Bagiński M., Ragona L., Molinari H., MM/PBSA Analysis of molecular dynamics simulations of bovine ?-lactoglobulin: free energy gradients in conformational transitions? Proteins 2005, vol. 59, 91-103.


  66. Hąc-Wydro K., Dynarowicz-Łątka P., Grzybowska J., Borowski E., How does the N-acylation and esterification of amphotericin B molecule affect its interactions with cellular membrane components - the Langmuir monolayer study., Coll. Surf. B 2005, vol. 46, 7-19.


  67. Hąc-Wydro K., Dynarowicz-Łątka P., Grzybowska J., Borowski E., Interactions of Amphotericin B derivative of low toxicity with biological membrane components - the Langmuir monolayer approach., Biophys. Chem. 2005, vol. 116, 77-88.


  68. Hąc-Wydro K., Dynarowicz-Łątka P., Grzybowska J., Borowski E., N-(1- Piperidinepropionyl)amphotericin B methyl ester (PAME) - a new derivative of the antifungal antibiotic amphotericin B: Searching for the mechanism of its reduced toxicity., J. Colloid Interf. Sci. 2005, vol. 287, 476-484.


  69. Hiszczyńska-Sawicka E., Kur J., Pietkiewicz H., Holec L., Gasior A., Myjak P., Efficient production of the Toxoplasma gondii GRA6, p35 and SAG2 recombinant antigens and their applications in the serodiagnosis of toxoplasmosis. Acta Parasitol. 2005, vol. 50, 249-254.


  70. Hyży M., Bożko P., Konopa J., Składanowski A., Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells. Biochem. Pharmacol. 2005, vol. 69, 801- 809.


  71. Kur J., Olszewski M., Długołęcka A., Filipkowski P. Single-stranded DNA-binding proteins (SSBs) - sources and applications in molecular biology. Acta Biochim. Polon. 2005, vol. 52, 569-574.


  72. Lemke K., Wojciechowski M., Laine W., Bailly Ch., Colson P., Bagiński M., Larsen A.K., Składanowski A., Induction of unique structural changes in guanine-rich DNA regions by the triazoloacridone C-1305, a topoisomerase II inhibitor with antitumor activities., Nucl. Acids Res. 2005, vol. 33, 6034-6047.


  73. Liberek B., Melcer A., Osuch A., Wakieć R., Milewski S., Wiśniewski A., N-Alkyl derivatives of 2-amino-2-deoxy-D-glucose., Carbohydr. Res. 2005, vol. 340, 1876-1884.


  74. Nowak R., Baranowska-Bosiacka I., Stefańska B., Machaliński B., Hłyńczak A.J., Tarasiuk J., The effect of new non-cross resistant antitumor agents on the energy state of human erythrocytes., Acta Biochim. Polon. 2005, vol. 52, 953-957.


  75. Olchowy J., Jędrzejczak R., Milewski S., Rypniewski W., Crystallization and preliminary X-ray analysis of the isomerase domain of glucosamine-6-phosphate synthase from Candida albicans., Acta Crystall, 2005, vol. F61, 994-996.


  76. Olszewski M., Rębała K., Szczerkowska Z., Kur. J., Application of SSB- like protein from Thermus aquaticus in multiplex PCR of human Y-STR markers identification. Mol. Cell Probe 2005, vol. 19, 203-205.


  77. Pawlak J., Sowiński P., Bieszczad T., Borowski E., The structure of Levorin, a minor component of Levorin complex., Pol. J. Chem. 2005, vol. 79, 1667-1672.


  78. Pawlak J., Tabin P., Sowiński P., Borowski E., The structure of Nystatin A2., Pol. J. Chem. 2005, vol. 79, 1673-1679.


  79. Piątek R., Zalewska B., Bury K., Kur J., The chaperone-usher pathway of bacterial adhesin biogenesis - from molecular mechanism to strategies of anti-bacterial prevention and modem vaccine design. Acta Biochim. Polon. 2005, vol. 52, 639-646.


  80. Piątek R., Zalewska B., Kołaj O., Ferens M., Nowicki B., Kur J., Molecular aspects of biogenesis of Escherichia coli Dr Fimbriae: Characterization of DraB-DraE complexes. Infect. Immun. 2005, vol. 73, 135-145.


  81. Składanowski A., Come M.G., Sabisz M., Escargueil A.E., Larsen A.K., Down-regulation of DNA topoisomerase II alpha leads to prolonged cell cycle transit in G(2) and early M phases and increased survival to microtubule-interacting agents. Mol. Pharmacol., vol. 68, 625-634.


  82. Stanisławska-Sachadyn A., Paszko Z., Kluska A., Skasko E., Sromek M., Balabas A., Janiec-Jankowska A., Wiśniewska A., Kur J., Sachadyn P., Preliminary studies on DNA retardation by MutS applied to the detection of point mutations in clinical samples. Mutat. Res. Fund. Mol. M. 2005, vol. 570, 97-103.


  83. Stefańska B., Bontemps-Gracz M.M., Antonini I., Martelli S., Arciemiuk M., Piwkowska A., Rogacka D., Borowski E., 2,7-Dihydro-3H- pyridazino[5,4,3-kl]acridin-3-one derivatives, novel type of cytotoxic agents active on multidrug-resistant cell lines. Synthesis and biological evaluation. Bioorg. Med. Chem. 2005, vol. 13, 1969-1975.


  84. Szweda P., Kodowski R., Kur J. New effective sources of the Staphylococcus simulans lysostaphin. J. Biotechnol. 2005 vol. 117, 203- 213.


  85. Tarasiuk J., Mazerski J., Tkaczyk-Gobis K., Borowski E., Molecular basis of the low activity of antitumor anthracenediones, mitoxantrone and ametantrone, in oxygen radical generation catalyzed by NADH dehydrogenase. Enzymatic and molecular modelling studies., Eur. J. Med. Chem. 2005, vol. 40, 321-328.


  86. Tkaczuk K.L., Bujnicki J.M., Bialkowska A., Bielecki S., Turkiewicz M., Cieślinski H, Kur J. Molecular modelling of a psychrophilic beta- galactosidase. Biocatal. Biotransfor. 2005, vol. 23, 201-209.


  87. Treder A.P., Walkowiak A., Zgoda W., Andruszkiewicz R., A new approach to the synthesis of selectively protected (2S)-1,2,4-triaminobutane derivatives., Synthesis 2005, vol. 14, 2281-2283.


  88. Walkowiak A., Wakieć R., Bontemps-Gracz M.M., Andruszkiewicz R. , Glutamine analogues containing a keto function - novel inhibitors of fungal glucosamine-6-phosphate synthase., J. Enzyme Inhib. Med. Chem. 2005, vol. 20, 439-447.


  89. Wojciechowski M., Fogolari F., Bagiński M., Thermodynamic and electrostatic properties of ternary Oxytricha nova TEBP-DNA complex., J. Struct. Biol. 2005, vol. 152, 169-184.


  90. Wojciechowski M., Milewski S., Mazerski J., Borowski E., Glucosamine-6- phosphate synthase, a novel target for antifungal agents. Molecular modelling studies in drug design. Acta Biochim. Polon. 2005, vol. 52, 647-652.


  91. Zalewska B., Piątek R., Bury K., Samet A., Nowicki B., Nowicki S., Kur J., A surface-exposed DraD protein of uropathogenic Escherichia coli bearing Dr fimbriae may be expressed and secreted independently from DraC usher and DraE adhesin. Microbiology-SGM 2005, vol. 51, 2477- 2486.





     


    Rok 2004

  92. Szlinder- Richert J., Cybulska B., Grzybowska J., Bolard J., Borowski E. Interaction of amphotericin B and its low toxic derivative, N-methyl-N-D-fructosyl amphotericin B methyl ester, with fungal, mammalian and bacterial cells measured by the energy transfer method. Il Farmaco 2004, vol. 59, 289-296.



  93. Pawłowska J., Priebe W., Paine M.I., Wolf R. C., Borowski E., Tarasiuk J. The ability of new sugar-modified derivatives of antitumour anthracycline, daunorubicin, to stimulate NAD(P)H Oxidation in Different Cellular Oxidoreductase Systems: NADH Dehydrogenase, NADPH Cytochrome P450 Reductase, and Xanthine Oxidase. Oncology Research 2004, vol. 14, 469-474.


  94. Tarasiuk J., Majewska E., Seksek O., Rogacka D., Antonini I., Garnier-Suillerot A., Borowski E. The role of structural factors in the kinetics of cellular uptake of pyrazoloacridines and pyrazolopyrimidoakridines. Implications for overcoming multidrug resistance towards leukaemia K562/DOX cells. Biochem. Pharmacol. 2004, vol. 68, 1815-1823.


  95. Głowacka-Rogacka D., Arciemiuk M., Kupiec A., Bontemps-Gracz M., Borowski E., Tarasiuk J. The activity of latent benzoperimidine esters to inhibit P-glycoprotein and multidrug resistance-associated protein 1 dependent efflux of pirarubicin from several lines of multidrug resistant tumor cells. Cancer Detect. & Prevent. 2004, vol. 28, 283-293.


  96. Ślisz M., Cybulska B., Mazerski J., Grzybowska J., Borowski E. Studies of the effects of antifungal cationic derivatives of amphotericin B on human erythrocytes. J. Antibiot. 2004, vol. 57, 669-678.


  97. Andruszkiewicz R., Treder A. A convenient synthesis of (S)-O-benzyl-N-tert-butoxycarbonyl-beta-tyrosine. Polish J. Chem. 2004, vol. 78, 1081-1084.


  98. Andruszkiewicz R., Rożkiewicz D. An improved preparation of N2-tert-butoxycarbonyl- and N2-benzyloxycarbonyl-(S)-2,4-diaminobutanoic acids. Synthetic Commun. 2004, vol 34, 1049-1056.


  99. Gabriel I., Olchowy J., Stanisławska-Sachadyn A., Mio Toshiyuki, Kur J., Milewski Phosphorylation of glucosamine-6-phosphate synthase is important but not essential for germination and mycelial growth of Candida albicans. FEMS Microbiol. Lett. 2004, vol. 235, 73-80.


  100. Milewski S., Professor Edward Borowski and molecular aspects of chemotherapy. Polish J. Chem. 2004, vol. 78, 1003-1006.


  101. Sternal K., Czub J., Baginski M. Molecular aspects of the interaction between amphotericin B and a phospholipid bilayer: molecular dynamics studies. J. Mol. Model. 2004, vol. 10, 223-232.

  102. Astel A., Mazerski J., Polkowska Ż., Namieśnik J. Application of PCA and time series analysis in studies of precipitation in Tricity (Poland). Adv. Environm. Res. 2004, vol. 8, 337-349.


  103. Węsierska-Gądek J., Schloffer D., Gueorguieva M., Uhl M., Składanowski A. Increased susceptibility of PARP-1 KO cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest. Cancer Research 2004, vol. 64, 4487-4497.


  104. Lemke K., Poindessous V., Składanowski A., Larsen A.K. The antitumor triazoloacridone C-1305 is a topoisomerase II poison with unusual properties. Mol. Pharmacol. 2004, vol. 66, 1035-1042.


  105. Krawczyk, B., Samet, A., Bronk, M., Hellmann, A., Kur, J.: Emerging linezolid-resistant, vancomycin resistant Enterococcus faecium from a patent of a Haematological Unit in Poland. Pol. J. Microbiol. 2004, vol. 53, 193-196.


  106. Siondalski, P., Siebert, J., Samet, A., Bronk, M., Krawczyk, B., Kur, J.: Usefulness of the PCR technique for bacterial DNA detection in blood of the patients after “opened heart” operations. Pol. J. Microbiol. 2004, vol. 53, 145-149.

  107. Naumiuk, Ł., Baraniak, A., Gniatkowski, M., Krawczyk, B., Rybak, B., Sadowy, E., Samet, A., Kur, J.: Molecular epidemiology of Serratia marcescens In two hospitals In Gdańsk, Poland, over a 5-year period. J. Clin. Microbiol. 2004, vol. 42, 3108-3116.


  108. Pietkiewicz, H., Hiszczyńska-Sawicka, E., Kur, J., Petersem, E., Nielsen, H.V., Stankiewicz, M., Andrzejewska, I., Myjak, P.: Usefulness of Toxoplasma gondii-specific recombinant antigens In serodiagnosis of human toxoplasmosis. J. Clin. Microbiol. 2004, vol. 42, 1779-1781.


  109. Cota, E., Chen, H.A., Anderson, K.L., Simpson, P., Du Merle L., Bernier-Febreaur, C., Piatek, R., Zalewska, B., Nowicki, B., Kur, J., Le Bouguenec, C., Matthews, Letter to Editor: Complete resonance assignments of the ‘donor-strand’ AfaD: the afimbrial invasin from diffusely adherent E. coli. J. Biomol. NMR 2004, vol. 29, 411-412.




     


    Rok 2003

  110. Stanisławska-Sachadyn A., Sachadyn P., Jędrzejczak R., Kur J. Construction and purification of his6-Thermus thermophilus MutS protein. Protein Expres. Purif., 2003, vol. 28, 69-77.


  111. Pawłowska J., Tarasiuk T., Wolf C.R., Paine M.J.I., Borowski E., Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xantine oxidase. Oncology Research, 2003, vol. 13, 245-252.


  112. Janiak A.M., Hoffman M., Milewska M.J., Milewski Hydrophobic derivatives of 2-amino-2deoxy-D-glucitol-6-phosphate: A new type of D-glucosamine-6-phosphate synthase inhibitors with antifungal action. Bioorg. Medicinal Chem., 2003, vol. 11, 1653-1662.


  113. Marshall N.J., Andruszkiewicz R., Gupta S., Milewski S., Payne J.W. Structure-activityrelationships for a series of peptidomimetic antimicrobial prodrugs containing glutamine analogues. J. Antimicrob. Chemother., 2003, vol. 51, 821-831.

  114. Czajgucki Z., Sowiński P., Andruszkiewicz R. Synthesis of orthogonally protected (3R,4S)- and (3S,4S)-4,5-diamino-3-hydroxypentanoic acids. Amino Acids, 2003, vol. 24, 289-291.


  115. Stefańska B., Arciemiuk M., Bontemps-Gracz M.M., Dzieduszycka M., Kupiec A., Martelli S., BorowskiE. Synthesis and biological evaluation of 2,7-dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione derivatives, a novel group of anticancer agents active on a multidrug resistant cell line. Bioorg. Med. Chem., 2003, vol. 11, 561-572.


  116. Astel A., Mazerski J., Polkowska Ż., Zygmunt B., Namieśnik J. Effect of transregional transport of pollutants on atmospheric air quality in the Tricity area of Poland. Pol. J. Environm. Stud., 2003, vol. 12, 27-33.

  117. Mazerska Z., Sowiński P., Konopa J. Molecular mechanism of the enzymatic oxidation investigated for imidazoacridinone antitumor drug, C-1311. Biochem. Pharmacol., 2003, vol. 66, 1727-1736.

  118. Hiszczyńska-Sawicka, E., Brillowska-Dąbrowska, A, Dąbrowski, S., Pietkiewicz, H., Myjak, P., Kur, J. High yield expression and single-step purification of Toxoplasma gondii SAG1, GRA1, and GRA7 antigens in Escherichia coli. Protein Expr. Purif., 2003, vol. 27, 150-157.

  119. Krawczyk, B., Lewandowski, K., Bronk, M., Samet, A., Myjak, P., Kur, J.: Evaluation of a novel method based on amplification of DNA fragments surrounding rare restriction sites (ADSRRS fingerprinting) for typing strains of vancomycin-resistant Enterococcus faecium. J. Microbiol. Meth., 2003, vol. 52, 341-351.

  120. Stanisławska-Sachadyn, A., Sachadyn, P., Jędrzejczak, R., Kur, J. Construction and purification of his6-Thermus thermophilus MutS protein. Protein Expr. Purif., 2003, vol. 28, 69-77.


  121. Krawczyk, B., Naumiuk, Ł., Lewandowski, K., Baraniak, A., Gniadkowski, M., Samet, A., Kur, J. Evaluation and comparison of random amplification of polymorphic DNA, pulsed-field gel electrophoresis and ADSRRS-fingerprinting for typing Serratia marcescens outbreaks. FEMS Immunol. Med. Microbiol., 2003, vol. 38, 241-248.

  122. Olędzka, G., Dąbrowski, S., Kur, J. High-level expression, secretion, and purification of the thermostable aqualysin I from Thermus aquaticus YT-1 in Pichia pastoris. Protein Expr. Purif., 2003, vol. 29, 223-229.


  123. Zalewska, B., Piątek, R., Konopa, G., Nowicki, B., Nowicki, S., Kur, J. Chimeric Dr fimbriae with a Herpes Simplex Virus type 1 epitope as a model for a recombinant vaccine. Infect. Immun., 2003, vol. 71, 5505-5513.

  124. Turkiewicz, M., Kur, J., Białkowska, A, Cieśliński, H., Kalinowska, H., Bielecki, Antarctic marine bacterium Pseudoalteromonas sp. 22b as a source of cold-adapted β-galactosidase. Biomol. Eng., 2003, vol. 20, 317-324.

  125. Skowron, P.M., Majewski, J., Żylicz-Stachula, A., Rutkowska, S.M., Jaworowska, J., Harasimowicz-Słowińska, R.I. A new Thermus sp. class-IIS enzyme sub-family: isolation of a ‘twin’ endonuclease TspDTI with a novel specificity 5’-ATGAA(N11/9)-3’, related to TspGWI, TaqII and Tth111II. Nucl. Acids Res. 2003, vol. 31, e74.


  126. Bartoszek A., Sielenko A., Węsiora M. Versatile method employing basic techniques of genetic engineering to study the ability of low-molecular weight compounds to bind covalently with DNA in cell-free systems. Anal. Biochem., 2003, vol 313, 53-59.

  127. Polkowska Z., Kozłowska K., Mazerska Z., Górecki T., Namieśnik J. Relationship between volatile organohalogen compounds in drinking water and human urine in Poland. Chemosphere, 2003, vol. 53, 899-909.

  128. Mazerska Z. Similarity between enzymatic and electrochemical oxidation of 2-hydroxy-acridinone, the reference compound of antitumor imidazoacridinones. Acta Biochim. Polon., 2003, vol. 50, 515-525.


  129. Antonini I., Polucci P., Magnano A., Cacciamani D., Konieczny M.T., Paradziej-Łukowicz J., Martelli Rational design, synthesis and biological evaluation of triadiazinoacridines: A new class of antitumor agents. Bioorg. Med. Chem., 2003, vol. 11, 399-405.

  130. Mazerska Z., Zon A., Stojek Z. Electrochemical formation of the adduct between antitumor agent C-1311 and DNA nucleoside dG. Electrochem. Commun., 2003, vol. 5, 770-775.

  131. Larsen A.K., Escargueil A.E., Skladanowski A. From DNA damage to G2 arrest: the many roles of topoisomerase II. Prog. Cell Cyc. Research (L. Meijer, A. Jezequel, M. Roberge, eds.) Volume 5, Plenum Press, New York, 2003, 295-300.


  132. Larsen A.K., Escargueil A.E., Skladanowski A. Catalytic topoisomerase II inhibitors in cancer therapy. Pharmacol. Therapeut., 2003, vol. 99, 167-181.



     


    Rok 2002

  133. Andruszkiewicz, R., Wyszogrodzka, M. Efficient synthesis of N-benzyloxycarbonyl- and N-tert-butyloxycarbonyl-(S)-isoserine and their derivatives. Synlett, 2002, 2101-2103.

  134. Baginski M., Polucci P., Antonini I., Martelli Binding free energy of selected anticancer compounds to DNA – theoretical calculations. J. Mol. Model., 2002, vol. 8, 24-32.

  135. Resat H., Baginski M. Ion passage pathways and thermodynamics of the amphotericin B membrane channel. Eur. Biophys. J., 2002, vol. 31, 294-305.

  136. Baginski M., Resat H., Borowski E. Comparative molecular dynamics simulations of amphotericin B – cholesterol/ergosterol membrane channels. Biochim Biophys. Acta, 2002, vol. 1567, 223-228.


  137. Zielkiewicz J., Mazerski J. Solvation of N-methylformamide by ethanol – a comparison of MD calculations with the experimental data. J. Phys. Chem. B, 2002, vol. 106, 861-869.


  138. Baran M., Mazerski J. Molecular modelling of membrane sterols with the use of the GROMOS96. Chem. Phys. Lipids, 2002, vol. 120, 21-31.

  139. Baran M., Mazerski J. Molecular modelling of amphotericin B-ergosterol primary complex in water. Biophys. Chem., 2002, vol. 95, 125-138.


  140. Bontemps-Gracz M.M., Kupiec A., Antonini I., Borowski E. The Ability to Overcome Multidrug Resistance of Tumor Cell Lines by Novel Acridine Cytostatics with Condensed Heterocyclic Rings. Acta Biochim. Polon., 2002, vol. 49, 87-92.


  141. Dzieduszycka M., Martelli S., Arciemiuk M., Bontemps-Gracz M.M., Kupiec A., Borowski E. Effect of Modification of 6-[(Aminoalkyl)amino]-7H-benzo[e]-perimidin-7-ones on Their Cytotoxic Activity toward Sensitive and Multidrug Resistant Tumor Cell Lines. Synthesis and Biological Evaluation. Bioorg. Med. Chem., 2002, vol. 10, 1025-1035.


  142. Tarasiuk J., Stefańska B., Plodzich I., Tkaczyk-Gobis K., Seksek O., Martelli S., Garnier-Suillerot, Borowski E. Anthrapyridones, a novel group of antitumour non-cross resistant anthraquinone analogues. Synthesis and molecular basis of the cytotoxic activity towards K562/DOX cells. Brit. J. Pharmacol., 2002, vol. 135, 1513-1523.


  143. Milewski Glucosamine-6-phosphate synthase – the multi-facets enzyme. Biochim. Biophys. Acta, 2002, vol. 1597, 173-192.


  144. Smitri, Krishnamurthy S., Dixit B. I., Gupta C. M., Milewski S., Prasad R. ABC transporters Cdr1p, Cdr2p i Cdr3p of a human pathogen Candida albicans are general phospholipid translocators. Yeast, 2002, vol. 19, str. 303-318.

  145. Janiak A. M., Cybulska B., Szlinder-Richert J., Borowski E., Milewski Facilitated diffusion of glucosamine-6-phosphate synthase inhibitors enhances their antifungal activity. Acta Biochim. Polon., 2002, vol. 49, 77-86.

  146. Cybulska B., Kupczyk K., Szlinder-Richert J., Borowski E. Comparativa in vitro studies on liposomal formulations of amphotericin B and itsderivative, N-methyl-N-D-fructosyl amphotericin B methyl ester (MFAME). Acta Biochim. Polon., 2002, vol. 49, 67-75.

  147. Mazerska Z., Zamponi S., Marassi R., Sowiński P., Konopa J. The products of electro- and photochemical oxidation of 2-hydroxyacridinone, the reference compound of antitumor imidazoacridinone derivatives. J. Electroanalyt. Chem., 2002, vol. 521, 144-154.


  148. Krawczyk, B., Lewandowski, K., Kur, J. Comparative studies of the Acinetobacter genus and the species identification method based on the recA seguences. Mol. Cel. Probes, 2002, vol. 16, 1-11.

  149. Szostakowska, B., Myjak, P. Kur, J. Identification of anisakid nematodes from the Southern Baltic Sea using PCR-based methods. Mol. Cel. Probes, 2002, vol. 16, 111-118.

  150. Żylicz-Stachula, A., Harasimowicz-Słowińska, R.I., Sobolewski, I. Skowron, P.M. TspGWI, a thermophilic class-IIs restriction endonuclease from Thermus sp., recognizes novel asymmetric sequence 5’-ACGGA(N11/9)-3’. Nucleic Acids Res., 2002, vol. 30, e33.

  151. Hasan, R.J., Pawelczyk, E., Urvil, P.T., Venkatarajan, M.S., Goluszko, P., Kur, J. Selvarangan, R., Nowicki, S., Braun, W.A., Nowicki, B.J. Structure-function analysis of decay-accelerating factor: identification of residues important for binding of the Escherichia coli Dr adhesin and complement regulation. Infect. Immun., 2002, vol. 70, 4485-4493.

  152. Dąbrowski, S., Olszewski, M., Piątek, R., Kur, J. Novel thermostable ssDNA-binding proteins from Thermus thermophilus and T. aquaticus – expression and purification. Protein Expr. Purif., 2002, vol. 26, 131-138.

  153. Dąbrowski, S., Olszewski, M., Piątek, R., Brillowska-Dąbrowska, A., Konopa, G., Kur, J. Identification and characterization of single-stranded-DNA-binding proteins from Thermus thermophilus and Thermus aquaticus – new arrangement of binding domains. Microbiology, 2002, vol. 148, 3307-3315.


  154. Skladanowski A. Modulation of G2 arrest enhances cell death induced by the antitumor 1-nitroacridine derivative, Nitracrine. Apoptosis, 2002, vol. 7, 347-359.


  155. Bożko P., Larsen A.K., Raymond E., Skladanowski A. Influence of G2 arrest in the cytotoxicity of topoisomerase inhibitors toward human carcinoma cells with different p53 status. Acta Biochim. Polonica, 2002, vol. 49, 109-119.


  156. Dzięgielewski J., Ślusarski B., Konitz A., Skladanowski A., Konopa J. Intercalation of imidazoacridones to DNA and its relevance to cytotoxic and antitumor activity. Biochem. Pharmacol., 2002, vol. 63, 1653-1662.


  157. Bartoszek A. Metabolic activation of adriamycin by NADPH-cytochrome P450 reductase overview of its biological and biochemical effects. Acta Biochim. Polonica, 2002, vol. 49, 323-331.

  158. Konopa J. Antitumor acridines with diaminoalkylo pharmacophoric group. Pur. Appl. Chem., 2002, vol. 73, 1421-1428.

     


    Rok 2001

  159. Andruszkiewicz R., Walkowiak A. A facile synthesis of N2-benzyloksycarbonyl-(S)-2-amino-3-(dimethylamino)propanoic acid. Org. Prep. Proced. Int., 2001, vol. 33, 379-381.

  160. Szlinder-Richert J., Mazerski J., Cybulska B., Grzybowska J., Borowski E. MFAME, N-methyl-N-D-fructosyl amphotericin B methyl ester, a new amphotericin B derivative of low toxicity: relationship between self-association and effects on red blood cells. Biochim. Biophys. Acta, 2001, vol. 1528, str. 15-24.

  161. Milewski S., Mignini F., Prasad R., Borowski E. Unusual susceptibility of a multidrug-resistant yeast strain to peptidic antifungals. Antimicrob. Agents Chemother., 2001, vol. 45, 223-228.


  162. Janiak A., Milewski Mechanism of antifungal action of kanosamine. Medical Mycology, 2001, vol. 39, 401-408.


  163. Zgódka D., Milewski S., Borowski E. A diffusible analoque of N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid with antifungal activity. Microbiology, 2001, vol. 147, 1955-1959.


  164. Zgódka D., Jędrzejczak R., Milewski S., Borowski E. Amide and ester derivatives of N3-(4-methoxyfumaroyl)-(S)-2,3-diaminopropanoic acid: the selective inhibitor of glucosamine-6-phosphate synthase. Bioorg. Medic. Chem., 2001, vol. 9, 931-938.

  165. Tkaczyk-Gobis K., Tarasiuk J., Seksek O., Stefańska B., Borowski E., Garnier-Suillerot A. Transport of new non-cross-resistant antitumor compounds of the benzoperimidine family in multidrug resistant cells. Eur. J. Pharmacol., 2001, vol. 413, 131-141.


  166. Szweda, P., Pladzyk, R., Kotłowski, R., Kur, J. Cloning, expression, and purification of the Staphylococcus simulans lysostaphin using the intein-chitin-binding domain (CBD) system. Protein Expr. Purif., 2001, vol. 22 467-471.

  167. Reichman, G., Długońska, H., Hiszczyńska-Sawicka, E., Fischer, H.G. Tachyzoite-specific isoform of Toxoplasma gondii lactate dehydrogenase is the target antigen of a murine CD4+ T-cell clone. Microb. Infect., 2001, vol. 3, 779-787.


  168. Zalewska, B., Piątek, R., Cieśliński, H., Nowicki, B., Kur, J. Cloning, expression, and purification of the uropathogenic Escherichia coli invasin DraD. Protein Expr. Purif. 2001, vol. 23, 476-482.

  169. Szostakowska, B., Myjak, P., Kur, J., Sywula, T. Molecular evaluation of Hysterothylacium auctum (Nematoda, Ascaridida, Raphidascarididae) taxonomy from fish of the southern Baltic. Acta Parasitologica, 2001, vol. 46, 194-201.

  170. Mazerska Z., Dzięgielewski J., Konopa J. Enzymatic activation of a new antitumor drug, 5-diethylaminoethylamino-8-hydroxyimidazoacridinone, C-1311, observed after its intercalation into DNA. Biochem. Pharmacol., 2001, vol. 61, 685-694.

  171. Składanowski A., Koba M., Konopa J. Does the antitumor cyclopropylpyrroloindole antibiotic CC-1065 cross-link DNA in tumor cells? Biochem. Pharmacol., 2001, vol. 61, 67-72.


  172. Gorlewska K., Mazerska Z., Sowiński P., Konopa J. Products of metabolic activation of the antitumor drug ledakrin (Nitracrine) in vitro. Chem. Res. Toxicol., 2001, vol. 14, 1-10.

  173. Konieczny M.T., Horowska B., Kunikowski A., Konopa J., Wierzba K., Asao Y.Y.T. Synthesis of polyhydroxylated derivatives of phenyl vinyl sulfone as structural analogs of chalcones. J. Synt. Org. Chem., 2001, vol. 9, 1363-1367.


  174. Konopa J. Antitumor acridines with diaminoalkylo pharmacophoric group. Pure Appl. Chem., 2001, vol. 73, 1421-1428.


  175. Escargueil A.E., Plisov S., Skladanowski A., Borgne A., Meijer L., Gorbsky G.J., Larsen A.K. Recruitment of cdc2 kinase by DNA topoisomerase II is coupled to chromatin remodeling. FASEB J., 2001, DOI 10.1096/fj.00-0726fje.

     


         Rok 2000
     

  176. Sachadyn, P., Jędrzejczak, R., Milewski, S., Kur, J., Borowski, E. Purification to homogeneity of Candida albicans glucosamine-6-phosphate synthase overexpressed in Escherichia coli. Protein Expr. Purif., 2000, vol. 19, 343-349.


  177. Andruszkiewicz, R., Jędrzejczak, R., Zieniawa, T., Wojciechowski, M., Borowski, E. N3-Oxoacyl derivatives of L-2,3-diaminopropanoic acid and their peptides; novel inhibitors of glucosamine-6-phosphate synthase. J. Enzyme Inhibition, 2000, vol. 15, 420-441.


  178. Resat, H., Sungur, F.A., Bagiński, M., Borowski, E., Aviyente, V. Conformational properties of amphotericin B amide derivatives - impact on selective toxicity. J. Comput. Aid. Mol. Des., 2000, vol. 14, 689-703


  179. Bagiński, M., Tereszczyn, A., Resat, H., Borowski, E. Distribution of molecular electrostatic potential of structures formed by amphotericin B in membrane. Biophys J., 2000, vol. 78, 177A Part 2.


  180. Borowski, E. Novel approaches in the rational design of antifungal agents of low toxicity. Il Farmaco, 2000, vol. 55, 206-208.


  181. Shugar, D., Rode, W., Borowski, E. Chemotherapy: Molecular Aspects – Preface. Acta Biochim. Polon., 2000, vol. 47, U3-U4.


  182. Garcia-Chaumont, Ch., Seksek, O., Grzybowska, J., Borowski, E., Bolard, J. Delivery systems for antisense oligonucleotides. Pharmacol. Therap., 2000, vol.87, 255-277.


  183. Szlinder-Richert, J., Cybulska, B., Grzybowska, J., Borowski, E., Prasad, R. Comparative studies on cell stimulatory, permeabilizing and toxic effects induced in sensitive and multidrug resistant fungal strains by amphotericin B (AMB) and N-methyl-N-D-fructosyl amphotericin B methyl ester (MFAME). Acta Biochim. Polon., 2000, vol.47, 133-140.


  184. Cybulska, B., Gadomska, I., Mazerski, J., Grzybowska, J., Borowski, E., Cheron, M.,Bolard, J. N-methyl-N-D-fructosyl amphotericin B methyl ester (MF-AME), a novel antifungal agent of low toxicity: Monomer/micelle control over selective toxicity. Acta Biochim. Polon., 2000, vol. 47, 121-131.


  185. Pawłowska, J., Tarasiuk, J., Borowski, E., Wąsowska, M., Oszczapowicz, I., Wolf, C.R. The ability of new formamide sugar-modified derivatives of daunorubicin to stimulate free radical formation in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase and xanthine oxidase. Acta Biochim. Polon., 2000, vol. 47, 121-131.


  186. Mazerski, J., Antonini, I., Martelli, The role of side chains in the interaction of new antitumor pyrimidoacridinetriones with DNA: Molecular dynamics simulation. Acta Biochim. Polon., 2000, vol. 47, 47-57.


  187. Mazerski, J., Muchewicz, K. The intercalation of imidazoacridinones into DNA induces conformational changes in their side chain. Acta Biochim. Polon., 2000, vol. 47, 65-78.


  188. Shugar, D., Borowski, E. Molecular Aspects of Chemotherapy – Preface. Pharmacol. Therap., 2000, vol. 85, 1.


  189. Dąbrowski, S., Sobiewska, G., Maciuńska, J., Synowiecki, J., Kur, J. Cloning, expression, and purification of the His(6)-tagged thermostable beta-galactosidase from Pyrococcus woesei in Escherichia coli and some properties of the isolated enzyme. Protein Expr. Purif., 2000, vol. 19/1, 107-12.


  190. Sachadyn, P., Stanisławska, A., Kur, J. One tube mutation detection using sensitive fluorescent dyeing of MutS protected DNA. Nucleic Acids Res. 2000, vol. 28/8, e36.


  191. Dąbrowski, S., Brillowska-Dąbrowska A., Kur, J. Fluorescent protein vector for directional selection of PCR clones. BioTechniques, 2000, vol. 29/4, 800-6.


  192. Kotłowski, R., Myjak, P., Kur, J. Specific detection of Amanita phalloides mycelium and spores by PCR amplification of the gpd (glyceraldehyde-3-phosphate dehydrogenase) gene fragment. J. Food Biochem., 2000, vol. 24/3, 201-212, 4 rys. bibliogr. 26 poz.


  193. Myjak, P., Kur, J., Pietkiewicz, H., Kotłowski, A., Nahorski, W., Szostakowska, B. Molecular differentiation of Entamoeba histolytica and E. dispar from stool and culture samples obtained from Polish citizens infected in tropics and in Poland. Acta Protozool., 2000, vol. 39, 217-24.


  194. Stańczak, J., Kubica-Biernat, B., Racewicz, M., Kruminis-Łozowska, W., Kur, J. Detection of three genospecies of Borrelia burgdorferi sensu lato in Ixodes ricinus ticks collected in different regions of Poland. Int. J. Med. Microbiol., 2000, vol. 290, 559-566.


  195. Larsen A.K., Escargueil A.E., Składanowski A. Resistance mechanisms associated with altered intracellular distribution of anticancer agents. Pharmac. Ther., 2000, vol. 85, 217-229.


  196. Składanowski A., Konopa J. Mitoxantrone and ametantrone induce DNA crosslinks in tumor cells. Br. J. Cancer., 2000, vol. 82, 1300-1304.

     

Wykaz patentów zgłoszonych i przyznanych, w Polsce i za granicą.

Uczestnicy Centrum opatentowali bądź zgłosili do opatentowania łącznie ok. 70 wynalazków. Poniżej wymienione są jedynie wybrane wynalazki z okresu ostatnich kilkunastu lat:

 

  1. Nowe pochodne kwasu D-trans-2,3-epoksybursztynamoilo-L-2,3-diaminopropanowego i sposób ich otrzymywania.
    Andruszkiewicz, R., Zieniawa, T., Borowski, E.
    Patent Polski, nr 176383, opublik. WUP 31.05.1999.
    Uwaga: Przekazane autorom w 2000 r.

  2. Pochodne N-metylo-N-glikozylowe estrów metylowych antybiotyków z grupy makrolidów polienowych i ich sole oraz sposób ich otrzymywania.
    Borowski, E., Grzybowska, J., Sowiński, P., Gumieniak, J., Czerwiński, A.
    Patent Polski nr 180253, z dnia 29.06.2000.

  3. 9-alkylamino-1-nitroacridine derivatives.
    Konopa, J., Wysocka-Skrzela, B., Tiwari, R.
    Patent USA nr 6589961, z dnia 8.06.2003

  4. Acridone derivatives and preparation of 8-hydroxy-imidazoacridinone derivatives.
    Konieczny, M., Konopa, J.
    Patent Brit. nr 2317888, z dnia 8.04.1998

  5. Imidazoacridines and their antineoplastic use.
    Chołody, W., Konopa, J.
    Patent Brit. Nr 2253396, z dnia 10.08.1994 (patent rozszerzony na dalszych 19 krajów)

  6. Sposób otrzymywania nowych pochodnych kwasu L-2,3-diaminopropanowego o strukturze tripeptidów.
    Andruszkiewicz, R., Chmara, H., Milewski, S., Borowski, E.
    Patent Polski Nr 149997 z 1990
    Wersje zagraniczne: Pat. USA Nr 4,923,965 z 1990; Patent Europ. Nr 0353317 z 1990.

  7. Pochodne 6-[(aminoalkilo)amino]-8,11-dihydroxy-7H-benzo[e]perimidyn-7-onu.
    Stefańska, B., Dzieduszycka, M., Bontemps-Gracz, M., Tarasiuk, J., Martelli, S., Antonini, I., Borowski, E.
    Zgłoszenie Pat. UP-RP Nr P-317493 z 1996.

  8. Pochodne makrolidu polienowego, zastosowanie do wektorowania cząsteczek.
    Bolard, J., Garcia, C., Seksek, O., Borowski, E., Grzybowska, J.
    Zgłoszenie Pat. UP-RP Nr P-343365 z 1999.

     

 

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